If you run the drive non stop then make sure it is not in its carry case and has full airflow access, ie: don't bury it with papers or other stuff.
The little mini Firewire case is going to work fine used constantly. It does not have fans cooling it so its temperatures will run a little higher than a bigger desktop enclosure with fans. My testing still showed them to run under 110 degree drive temperature in a 75 degree office environment. This is well below what those drives run inside a portable computer. This will give us a longer drive life in the mini case than inside your MacBook.
If the drive were empty it would do ok as a scratch drive. But a half full 2.5 inch drive is not very fast compared to a near empty 3.5 inch drive. Yes, it helps to separate off some of the disk access to another drive - any other drive. A small platter size drive is somewhat down the performance list of hard drives when that list includes the larger 3.5 inch drives. You will see some performance gains dedicating one to scratch but they will be modest compared to a bigger drive doing the same tasks.
Rick
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Molôn Labé!
Quad 2.5GHz G5, 8GB RAM(Macgurus, of course:), OS10.5.x, lots of test stuff, LogiTech Laser moose
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